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Low-cost air quality sensors (LCSs) are becoming more ubiquitous as individuals and communities seek to reduce their exposure to poor air quality. Compact, efficient, and aesthetically designed sensor housings that do not interfere with the target air quality measurements are a necessary component of a low-cost sensing system. The selection of appropriate housing material can be an important factor in air quality applications employing LCSs. Three-dimensional printing, specifically fused deposition modeling (FDM), is a standard for prototyping and small-scale custom plastics production because of its low cost and ability for rapid iteration. However, little information exists about whether FDM-printed thermoplastics affect measurements of trace atmospheric gasses. This study investigates how five different FDM-printed thermoplastics (ABS, PETG, PLA, PC, and PVDF) affect the concentration of five common atmospheric trace gasses (CO, CO2, NO, NO2, and VOCs). The laboratory results show that the thermoplastics, except for PVDF, exhibit VOC off-gassing. The results also indicate no to limited interaction between all of the thermoplastics and CO and CO2 and a small interaction between all of the thermoplastics and NO and NO2.